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A Boronic Acid-Based Fluorescence Hydrogel for Monosaccharide Detection

submitted on 07.10.2018, 09:15 and posted on 09.10.2018, 12:20 by Suying Xu, Adam Sedgwick, Souad Elfecky, Wenbo Chen, Ashley Jones, George Williams, Toby Jenkins, Steven Bull, John Fossey, Tony James

A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection. In solution, the fluorescent probe displayed a strong fluorescence turn-on response upon exposure to fructose, and an expected trend in apparent binding constants, as judged by a fluorescence response where D-fructose > D-galactose > D-mannose > D-glucose. The hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of fructose resulting in a 10-fold enhancement (≤ 0.25 M).


EPSRC and DTI (DT/F00267X/1); University of Bath Enterprise Development Fund(EDF); Leverhulme Trust (F00094BC); JDRF (2-SRA-2016-267-A-N)


Email Address of Submitting Author


University of Bath


United Kingdom

ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest


Read the published paper

in Frontiers of Chemical Science and Engineering