ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

A Boronic Acid-Based Fluorescence Hydrogel for Monosaccharide Detection

preprint
submitted on 07.10.2018 and posted on 09.10.2018 by Suying Xu, Adam Sedgwick, Souad Elfecky, Wenbo Chen, Ashley Jones, George Williams, Toby Jenkins, Steven Bull, John Fossey, Tony James

A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection. In solution, the fluorescent probe displayed a strong fluorescence turn-on response upon exposure to fructose, and an expected trend in apparent binding constants, as judged by a fluorescence response where D-fructose > D-galactose > D-mannose > D-glucose. The hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of fructose resulting in a 10-fold enhancement (≤ 0.25 M).

Funding

EPSRC and DTI (DT/F00267X/1); University of Bath Enterprise Development Fund(EDF); Leverhulme Trust (F00094BC); JDRF (2-SRA-2016-267-A-N)

History

Email Address of Submitting Author

t.d.james@bath.ac.uk

Institution

University of Bath

Country

United Kingdom

ORCID For Submitting Author

0000-0002-4095-2191

Declaration of Conflict of Interest

No conflict of interest

Exports

Read the published paper

in Frontiers of Chemical Science and Engineering

Logo branding

Exports