ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

preprint
submitted on 07.02.2020 and posted on 07.02.2020 by Amanda Acevedo-Jake, Andrew Ball, marzia Galli, Mikiembo Kukwikila, mathieu denis, Daniel Singleton, ali tavassoli, Stephen Goldup

We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

Funding

EPSRC (EP/L016621/1)

BBSRC (BB/J001694/2)

H2020 Marie Curie Individual Fellowship (798304, AAJ)

Royal Society Wolfson Fellowship (SMG)

History

Email Address of Submitting Author

s.goldup@soton.ac.uk

Institution

University of Southampton

Country

United Kingdom

ORCID For Submitting Author

0000-0003-3781-0464

Declaration of Conflict of Interest

None

Version Notes

Submitted version of manuscript

Exports

Read the published paper

in Journal of the American Chemical Society

Logo branding

Exports