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3D Printed Tetrakis(triphenylphosphine)palladium (0) Impregnated Stirrer Devices for Suzuki-Miyaura Cross-Coupling Reactions

preprint
submitted on 13.08.2020 and posted on 13.08.2020 by Matthew Penny, Zenobia Rao, Ahtsham Ishaq, Rumintha Thavarajah, Stephen Hilton
3D printed materials can be readily modified to create bespoke structures that incorporate a range of catalysts at the point of printing. In this present study we report on the design and 3D printing of tetrakis (triphenylphosphine) palladium (0) impregnated 3D printed stirrer devices that were used to catalyze a Suzuki-Miyaura reaction between biaryl compounds in a batch-based approach. It was shown that the devices themselves are reusable, easy to use, air-stable, give access to an array of biaryl compounds in excellent yields and lead to low levels of palladium loss into the reaction. Simple modification of the device’s design by size reduction, meant that they could also be used to reduce the time of the Suzuki-Miyaura reaction by microwave enhanced heating. At the end of the reaction, devices can simply be removed from the flask, washed and reused, analogous to stirrer bead workflows. This makes the overall process of setting up multiple reactions simpler by obviating the need to weigh out catalysts for reactions and the device, once used, can be simply removed from the reaction media at the end of the reaction.

Funding

EPSRC - 1810639

History

Email Address of Submitting Author

s.hilton@ucl.ac.uk

Institution

UCL School of Pharmacy

Country

United Kingdom

ORCID For Submitting Author

0000-0001-8782-4499

Declaration of Conflict of Interest

no conflict of interest

Version Notes

This is version 1.0

Exports