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3D printed materials can be readily modified to
create bespoke structures that incorporate a range of catalysts at the point of
printing. In this present study we report on the design and 3D printing of
tetrakis (triphenylphosphine) palladium (0) impregnated 3D printed stirrer
devices that were used to catalyze a Suzuki-Miyaura reaction between biaryl
compounds in a batch-based approach. It was shown that the devices themselves
are reusable, easy to use, air-stable, give access to an array of biaryl
compounds in excellent yields and lead to low levels of palladium loss into the
reaction. Simple modification of the device’s design by size reduction, meant
that they could also be used to reduce the time of the Suzuki-Miyaura reaction
by microwave enhanced heating. At the end of the reaction, devices can simply be
removed from the flask, washed and reused, analogous to stirrer bead workflows.
This makes the overall process of setting up multiple reactions simpler by
obviating the need to weigh out catalysts for reactions and the device, once
used, can be simply removed from the reaction media at the end of the reaction.