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14N1H HMQC Solid-State NMR as a Powerful Tool to Study Amorphous Formulations – an Exemplary Study of Paclitaxel Loaded Polymer Micelles

preprint
submitted on 09.05.2020 and posted on 12.05.2020 by Marvin Grüne, Robert Luxenhofer, Dinu Iuga, Steven P. Brown, Ann-Christin Pöppler
We present 14N-1H HMQC MAS NMR experiments in the solid state as a promising tool to study amorphous formulations. Poly(2-oxazoline) based polymer micelles loaded with different amounts of the cancer drug paclitaxel serve to highlight the possibilities offered by these experiments: While the very similar 15N chemical shifts hamper a solid-state NMR characterization based on this nucleus, 14N is a very versatile alternative. 14N-1H HMQC experiments yield well-separated signals, which are spread over a large ppm range, provide information on the symmetry of the nitrogen environment and probe 14N-1H through-space proximities.

Funding

Newton International Fellowship Alumni Follow on Funding of the Royal Society (AL\180018)

The UK 850 MHz solid-state NMR Facility used in this research was funded by EPSRC and BBSRC (contract reference PR140003), as well as the University of Warwick including via part funding through Birmingham Science City Advanced Materials Projects 1 and 2 supported by Advantage West Midlands (AWM) and the European Regional Development Fund (ERDF).

History

Email Address of Submitting Author

ann-christin.poeppler@uni-wuerzburg.de

Institution

University of Würzburg

Country

Germany

ORCID For Submitting Author

0000-0002-0624-1708

Declaration of Conflict of Interest

No conflict of interest.

Version Notes

This is the inital version of the manuscript prior to any revisions.

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