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Terenzi_Manuscript_and_SI_ chemRxiv-2.pdf (4.85 MB)

124I-Radiolabeling of a Au(III)-NHC Complex for in Vivo Biodistribution Studies

preprint
revised on 05.06.2020, 15:38 and posted on 08.06.2020, 08:14 by Federica Guarra, Alessio Terenzi, Christine Pirker, Rossana Passannante, Dina Baier, Ennio Zangrando, Vanessa Gómez, Tarita Biver, Chiara Gabbiani, Walter Berger, Jordi Llop, Luca Salassa
Au(III) complexes with N-Heterocyclic Carbenes (NHCs) ligands have shown remarkable potential as anticancer agents, yet their fate in vivo has not been thoroughly examined and understood. Herein we report on the synthesis of new Au(III)-NHC complexes via direct oxidation with radioactive [124I]I2 as a valuable strategy to monitor the in vivo biodistribution of this class of compounds using positron emission tomography (PET) and, in combination with in vitro analyses, to provide direct evidence of the importance of Au(III)-to-Au(I) reduction for achieving full anticancer activity.

History

Email Address of Submitting Author

lsalassa@dipc.org

Institution

Donostia International Physics Center

Country

Spain

ORCID For Submitting Author

0000-0002-2112-9095

Declaration of Conflict of Interest

No conflicts of interest

Version Notes

Version 2 expanded in vitro analysis

Exports