Utilizing Carbonyl-Coordination of Native Amides for Pd– catalyzed C(sp3)–H Olefination

2019-05-16T15:42:41Z (GMT) by Hojoon Park Yang Li jin-quan yu
<p>Pd(II)–catalyzed C(sp<sup>3</sup>)–H olefination of native amide substrates was developed. To utilize the extremely</p> <p>weak-coordinating carbonyl-coordination of amides, an electron-deficient pyridinesulfonic acid ligand</p> <p>was designed. Structurally diverse amide substrates, including lactams, underwent olefination without the</p> <p>undesired cyclization. Olefination products were further diversified through synthetic transformations on</p> <p>the alkenyl moiety.</p><br>