Small-Molecule (Micro)arrays for Sensitive Multiplex Metabolites Detection by Surface Plasmon Resonance Imaging

01 March 2018, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Small-molecule (micro)arrays were developed to measure three metabolites simultaneously by surface plasmon resonance imaging for the first time. To tackle the low sensitivity challenge associated with small molecule detection, antibodies were employed as the signal amplifiers. This work demonstrates both inhibition and displacement formats are applicable for sensitive multiplex metabolites detection.

Keywords

surface plasmon resonance imaging
multiplex assay
small-molecule metabolites
small-molecule microarrays

Supplementary materials

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AC4 ESI ChemRxiv
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