Silver-Catalyzed Decarboxylative Cross-coupling Radical Reaction: Direct Synthesis of Coenzyme Q Compounds

<p>An efficient and general method for the synthesis of Coenzyme Q compounds through the activation of 1,4-benzoquinone C<i><sub>sp2</sub></i>-H bond has been developed. This C-C bond formation reaction proceeds readily in an open flask by direct cross-coupling reaction of Coenzyme Q<sub>0</sub> with commercially available aliphatic carboxylic acids utilizing AgNO<sub>3</sub> as catalyst and K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> as oxidant in aqueous solution. This radical reaction is operationally simple and amenable to gram-scale synthesis. <sub></sub></p>