Regioselective C3-H Trifluoromethylation of 2H-Indazole Under Transition-Metal-Free Photoredox Catalysis

04 March 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Here we report a visible-light-promoted metal-free regioselective C3-H trifluoromehtylation reaction that proceeds via radical mechanism and which supported by control experiments. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the present trifluoromethylation reaction and synthesis of a library of trifluoromethylated indazoles.

Keywords

Regioselective Functionalization
indazole
photoredox reaction
C3-H Functionalization
trifluoromethylation

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