Redox Neutral and Acid-Free Minisci C-H Alkylation of Heteroarenes Enabled by Dual Photoredox/bromide Catalysis in Micellar Solutions

30 April 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Microstructured aqueous solutions were employed to engage non-activated alkyl bromides in the visible-light-promoted C‑H functionalization of heteroarenes. The reactive carbon-centered alkyl radicals were generated by merging the photoredox approach, bromide anion co-catalysis and spatial pre-aggregation of reacting species in the mixture. The presented methodology allowed obtaining alkylated heteroarenes without stoichiometric radical-promoters, in acid-free conditions and using blue LEDs as the light source.

Keywords

photoredox
photocatalysis
Minisci
heterocycles
heteroarenes
micelle
microheterogenous
light

Supplementary materials

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Giedyk et al SI
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