Radical Benzylation of Quinones via C–H Abstraction
2019-04-08T15:03:38Z (GMT) by
Herein we report the development of radical benzylation reactions of quinones using Selectfluor and catalytic Ag(I) initiators. The reaction is believed to proceed via a C–H abstraction mechanism after Ag(I)-mediated reduction of Selectfluor. This reaction occurs under mild conditions and is effective for a variety of quinones and radical precursors bearing primary ben-zylic carbons. The use of pre-formed Ag(4–OMePy)2NO3 as a catalyst proved effective in improving reaction efficiency by reducing unwanted degradation pathways available to Selectfluor.