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RNA Phosphorothioate Modification in Prokaryotes and Eukaryotes

preprint
revised on 13.01.2020 and posted on 14.01.2020 by Ying Wu, Yaning Tang, xiaolong dong, Ya Ying Zheng, Phensinee Haruehanroengra, song mao, Qishan Lin, Jia Sheng
We report the first RNA phosphorothioate modification in both prokaryotes and eukaryotes. The GpsG modification exists in the Rp configuration and was quantified with liquid chromatography coupled with tandem mass spectrometry. Furthermore, we show the Dnd clusters that regulate DNA PT modification also play roles in RNA PT modification.

Funding

NSF-1845486

History

Email Address of Submitting Author

jsheng@albany.edu

Institution

University at Albany, SUNY

Country

United States

ORCID For Submitting Author

0000-0001-6198-390X

Declaration of Conflict of Interest

The authors declare no conflict of interest.

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in ACS Chemical Biology

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