RNA Phosphorothioate Modification in Prokaryotes and Eukaryotes
2020-01-14T11:49:57Z (GMT) by
We report the first RNA phosphorothioate modification in both prokaryotes and eukaryotes. The GpsG modification exists in the Rp configuration and was quantified with liquid chromatography coupled with tandem mass spectrometry. Furthermore, we show the Dnd clusters that regulate DNA PT modification also play roles in RNA PT modification.