Protein-Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal
2019-11-17T23:01:36Z (GMT)
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A new lysine‐reactive cyclopropropyl aldehyde for the covalent modification of proteins was developed. The reagent exploits a divinylcyclopropane‐cycloheptadiene rearrangement to render the initial condensation irreversible. A labelling study on eGFP demonstrated excellent chemoselectivity for the modification of amine‐nucleophiles with the possibility of subsequent modifications.
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