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Manuscript_Delasoie et al_FZ_ESI.pdf (6.31 MB)

Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes

preprint
submitted on 21.04.2020, 20:13 and posted on 23.04.2020, 05:38 by Joachim Delasoie, Philippe Schiel, Sandra Vojnovic, Jasmina Nikodinovic-Runic, Fabio Zobi
Design, synthesis and characterization of a bio-inspired hybrid multifunctional drug delivery system based on diatom microalgae. The microalgae’s surface was chemically functionalized with hybrid vitamin B12-photoactivable molecules and the materials further loaded with highly active rhenium(I) tricarbonyl anticancer complexes. The constructs showed enhanced adherence to colorectal cancer (CRC) cells via transcobalamin (II) receptors and slow release of the chemotherapeutic drugs. The overall toxicity of the hybrid multifunctional drug delivery system was further enhanced by photoactivation of the microalgae surface. Depending on the construct and anticancer drug, a 2-fold increase in the cytotoxic efficacy of the drug was observed upon light irradiation.

Funding

Swiss National Science Foundation, Grant PP00P2_170589

Ministry of Education, Science and Technological Development of the Republic of Serbia, Project No.173048

History

Email Address of Submitting Author

fabio.zobi@unifr.ch

Institution

Université de Fribourg

Country

Switzerland

ORCID For Submitting Author

0000-0002-9077-7184

Declaration of Conflict of Interest

No conflict of interest.

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