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Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly
preprintrevised on 18.10.2018, 11:26 and posted on 18.10.2018, 13:22 by Essak Khan, Shrikrishnan Sankaran, Julieta Paez, Christina Muth, Mitchell Han, Aránzazu del Campo
Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assembly of cellular collagen is here demonstrated. This novel light-driven tool enables unprecedented fundamental studies of collagen biosynthesis and associated diseases.