ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Manuscript_final ChemRXIV_Kh_AdC.pdf (1.94 MB)

Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly

preprint
revised on 18.10.2018, 11:26 and posted on 18.10.2018, 13:22 by Essak Khan, Shrikrishnan Sankaran, Julieta Paez, Christina Muth, Mitchell Han, Aránzazu del Campo
Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assembly of cellular collagen is here demonstrated. This novel light-driven tool enables unprecedented fundamental studies of collagen biosynthesis and associated diseases.

History

Email Address of Submitting Author

essak.khan@leibniz-inm.de

Institution

INM-Leibniz Institute for New Materials

Country

Germany

ORCID For Submitting Author

0000-0001-5691-4854

Declaration of Conflict of Interest

The authors declare no conflict of interest.

Exports