Palladium-Catalyzed Denitrative Mizoroki–Heck Reaction

We have developed a Mizoroki–Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. Combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multi-functionalized arene in a one-pot operation.