Palladium-Catalyzed Denitrative Mizoroki–Heck Reaction

17 March 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We have developed a Mizoroki–Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. Combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multi-functionalized arene in a one-pot operation.

Keywords

Mizoroki–Heck reaction
alkenylation protocol
Palladium Catalysis
Nucleophilic Aromatic Substitutions
aryl electrophiles

Supplementary materials

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Title
nitroHeck SI 20200316ChemRxiv
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