On the Reactivity of mRNA Caps: C-H Oxidative Addition of 7-Methylguanosine to Pt(0)

20 May 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

7-methylguanosine, the so-called mRNA cap 0 bears a very labile C8-H bond, due to the formation of an ylide/N-heterocyclic carbene, upon proton loss. The reaction of 7-methylguanosine with Pt(PPh3)4, via C-H oxidative addition, yields a hydrido–PtII carbene complex and this reactivity can be extrapolated to 7,9-dimethylguanine.

Keywords

C-H activation
mRNA caps
N-heterocyclic carbene
platinum
guanosine compounds
nucleobase derivatives

Supplementary materials

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Supporting Information III
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