Modulation of Metal-Azolate Frameworks for the Tunable Release of Encapsulated Glycosaminoglycans

07 February 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

In this work, selected GAG-based biotherapeutics, including one proteoglycan, were successfully encapsulated with high efficiency in three different pH-responsive metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The GAG@MOF biocomposites obtained present significant differences in terms of crystallinity, particle size, and spatial distribution of the cargo, which enables to modulate their performance as drug delivery systems.

Keywords

drug delivery
glycosaminoglycans
Biomineralization
MOFs
biocomposites

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