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Modeling the Effects of O-sulfonation on the CID of Serine

preprint
submitted on 01.02.2020 and posted on 03.02.2020 by Kenneth Lucas, George Barnes
We present the results of direct dynamics simulations and DFT calculations aimed at elucidating the effect of \textit{O}-sulfonation on the collision induced dissociation for serine. Towards this end, direct dynamics simulations of both serine and sulfoserine were performed at multiple collision energies and theoretical mass spectra obtained. Comparisons to experimental results are favorable for both systems. Peaks related to the sulfo group are identified and the reaction dynamics explored. In particular, three significant peaks (m\z 106, 88, and 81) seen in the theoretical mass spectrum directly related to the sulfo group are analyzed as well as major peaks shared by both systems. Our analysis shows that the m\z 106 peaks result from intramolecular rearrangements, intermolecular proton transfer among complexes composed of initial fragmentation products, and at high energy side-chain fragmentation. The \mz 88 peak was found to contain multiple constitutional isomers, including a previously unconsidered, low energy structure. It was also seen that the RM1 semi empirical method was not able to obtain all of the major peaks seen in experiment for sulfoserine. In contrast, PM6 did obtain all major experimental peaks.

Funding

NSF 1763652

History

Email Address of Submitting Author

gbarnes@siena.edu

Institution

Siena College

Country

USA

ORCID For Submitting Author

0000-0001-9211-2736

Declaration of Conflict of Interest

None

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in Journal of the American Society for Mass Spectrometry

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