Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

06 May 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from in situ manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

Keywords

mechanochemistry
green synthesis
MIL-100
drug ecapsulation
host-guest interactions
grinding synthesis
spectroscopy characterizations

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