Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria

27 September 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal-complexes offer access to potential alternative modes of action and have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug resistant bacteria. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

Keywords

Rhenium
Organometallic
Light-activated
Bacteria
Antibiotic
E. coli bacteria
MRSA

Supplementary materials

Title
Description
Actions
Title
LightRe SupportingInformation Chemrxiv AngeloFrei
Description
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