Ligand Enabled Nickel-Catalyzed Asymmetric Hydroarylation of Styrenes and 1,3-Dienes with Arylboronic Acids

25 February 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A chiral spiro aminophosphine ligand enabled nickel-catalyzed asymmetric hydroarylation of styrenes and 1,3-dienes with arylboronic acids. The reaction was promoted by a Ni–H species generated from protonation of Ni(0) with alcohol. This reaction uses only catalytic amount reagents and provided an efficient, straightforward and mild method for preparing enantioenriched 1,1-diarylalkanes, which are important motifs for the synthesis of many biologically active molecules.

Keywords

Ligand Enabled
Nickel-Catalyzed
Asymmetric Hydroarylation of Styrenes and 1,3-Dienes

Supplementary materials

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SI-hydroarylation-2019.2.23
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