Interplay of Catalyst Structure and Temperature for NMR Signal Amplification by Reversible Exchange

2019-03-07T14:54:53Z (GMT) by Fan Shi
SABRE has brought up the many possibilities for chemical and medical researches. However, the current SABRE catalyst has multi-limitations, including the time-consuming activation, activation stability and temperature compatibility. In this report, synthesis of several variants of an iridium-based organometallic catalyst showed accelerated activation performance and enhanced stability, during NMR Signal Amplification By Reversible Exchange (SABRE) in solution under upon administration of parahydrogen (pH2)-enriched gas in methanol mixture containing the “variant” catalyst and the substrate (pyridine or nicotinamide). Furthermore, such series of newly discovered SABRE catalysts are opening a door to a much high activation efficiency and higher low temperature performances for the potential future applications in larger and more challenging application fields, as well the relevant theoretical study of SABRE mechanism.