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Homology Models of Coronavirus 2019-nCoV 3CLpro Protease

preprint
revised on 05.02.2020 and posted on 05.02.2020 by Martin Stoermer
A regional outbreak of pneumonia in Wuhan, Hubei Province of China in late 2019 was associated with a novel coronavirus. Rapid release of genomic data for the isolated virus enabled the construction of first-generation homology models of the new CoV 3CLpro cysteine protease. Whilst the overall viral genome was most closely associated with bat coronaviruses, the main protease is most closely related (96% identity) to SARS CoV protease.

History

Email Address of Submitting Author

martin.stoermer@uq.edu.au

Institution

The University of Queensland

Country

Australia

ORCID For Submitting Author

0000-0003-3445-2104

Declaration of Conflict of Interest

I declare that there are no conflicts of interest. This work is entirely derived from data in the public domain

Version Notes

17/01/2020 Initial ChemRxiv upload - awaiting feedback from data suppliers 20/01/2020 Submission 5/2/2019 - Revised title

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