![Author ORCID: We display the ORCID iD icon alongside authors names on our website to acknowledge that the ORCiD has been authenticated when entered by the user. To view the users ORCiD record click the icon. [opens in a new tab]](https://chemrxiv.org/engage/assets/public/chemrxiv/images/logos/orcid.png)
Abstract
Directed evolution of cytochrome P450 enzymes fine-tunes site selectivity of new-to-nature C‒H amidation for modular, sustainable and scalable preparation of enantio-enriched β-, γ- and δ-lactams.
Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis
13 February 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.
Comments
Comments are not moderated before they are posted, but they can be removed
by the site moderators if they are found to be in contravention of our
Commenting Policy
[opens in a new tab]
- please read this policy before you post. Comments should be used for
scholarly discussion of the content in question. You can
find more information about how to use the commenting feature here
[opens in a new tab]
.
This site is protected by reCAPTCHA and the Google
Privacy Policy
[opens in a new tab]
and
Terms of Service
[opens in a new tab]
apply.
Now Published
Site-selective enzymatic C‒H amidation for synthesis of diverse lactams [opens in a new tab]
Inha Cho, Zhi-Jun Jia, Frances H. Arnold journal article
Science , Volume 364, Issue 6440
Print publication date: May 10, 2019
Version History
Jan 03, 2020 Version
2
(Retracted)
Feb 13, 2019 Version 1
(Retracted)
Metrics
11,079
2,713
0
Views
Downloads
Citations
Author’s competing interest statement
Caltech has filed a provisional patent application (CIT-8187-P)