Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis

Inha Cho; Zhijun Jia; Frances H. Arnold

doi:10.26434/chemrxiv.7711418.v1

Biological and Medicinal Chemistry

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Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis

13 February 2019, Version 1

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Abstract

Directed evolution of cytochrome P450 enzymes fine-tunes site selectivity of new-to-nature C‒H amidation for modular, sustainable and scalable preparation of enantio-enriched β-, γ- and δ-lactams.

Keywords

C‒H Amidation

biocatalysis strategies

Cytochrome P450s

lactam ring

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