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Electrochemical TEMPO-Catalyzed Multicomponent C(sp3)-H α-Carbamoylation of Free Cyclic Secondary Amines

2019-06-10T18:39:03Z (GMT) by Na Pan Johanne Ling Jean-Pierre Pulicani Maxime R. Vitale Laurence Grimaud
We report here an original electrosynthetic method allowing the straightforward C(sp3)-H a-carbamoylation of free cyclic secondary amines. Based on a TEMPO-catalyzed indirect anodic oxidation and a multicomponent coupling, a wide variety of N-acyl alpha-carboxamides have been obtained in remarkably mild and sustainable reaction conditions.

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