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Electrochemical TEMPO-Catalyzed Multicomponent C(sp3)-H α-Carbamoylation of Free Cyclic Secondary Amines

10 June 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report here an original electrosynthetic method allowing the straightforward C(sp3)-H a-carbamoylation of free cyclic secondary amines. Based on a TEMPO-catalyzed indirect anodic oxidation and a multicomponent coupling, a wide variety of N-acyl alpha-carboxamides have been obtained in remarkably mild and sustainable reaction conditions.

Keywords

Electrosynthesis
Multicomponent reaction
C(sp3)-H functionalization
Carbamoylation
TEMPO
Anodic oxidation
Amines
isocyanides
Carboxylic acids

Supplementary materials

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Now Published

Electrochemical TEMPO-catalyzed multicomponent C(sp3)–H α-carbamoylation of free cyclic secondary amines [opens in a new tab]
Na Pan, Johanne Ling, Ramiro Zapata, Jean-Pierre Pulicani, Laurence Grimaud, Maxime R. Vitale journal article
Green Chemistry , Volume 21, Issue 22
Online publication date: 2019

Version History

Jun 10, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.8242418.v1
D O I: 10.26434/chemrxiv.8242418.v1 [opens in a new tab]

Author’s competing interest statement

no conflict of interest

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