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Ms_Final.pdf (4.87 MB)
Electroceutical Fabric Lowers Zeta Potential and Eradicates Coronavirus Infectivity upon Contact
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
submitted on 14.05.2020 and posted on 15.05.2020by Abhishek Sen, Dolly Khona, Subhadip Ghatak, Vinoj Gopalakrishnan, Kenneth Cornetta, Sashwati Roy, Savita Khanna, Chandan Sen
intact infectivity attached to PPE surfaces pose significant threat to the
spread of COVID-19. We tested the hypothesis that an electroceutical fabric,
generating weak potential difference of 0.5V, disrupts the infectivity of
coronavirus upon contact by destabilizing the electrokinetic properties of the
virion. Respiratory coronavirus particles (105) were placed in
direct contact with the fabric for 1 or 5 minutes. Viral particles (2.5-4x104)
were recovered from the fabric. Following one minute of contact, zeta potential
of the coronavirus was significantly lowered indicating destabilization of its
electrokinetic properties. Size-distribution plot showed appearance of
aggregation of the virus. Testing of the cytopathic effects of the virus showed
eradication of infectivity as quantitatively assessed by PI-calcein and MTT
cell viability tests. This work provides the rationale to consider the studied
electroceutical fabric, or other materials with comparable property, as
material of choice for the development of PPE in the fight against COVID-19.