Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Comparing in vitro 2D and 3D-tumor model of triple-negative breast cancer

05 December 2017, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This manuscript describes a ultra-high loaded nanoformulation of curcumin. This compound is extremely water insoluble but could be dissolved using poly(2-oxazoline)/poly(2-oxazine) based polymer amphiphiles. The resulting formulations were thoroughly characterized in solution and solid form by NMR, dynamic light scattering, electron microscopy, HPLC zeta potential measurements, XRD, respectively. Biological activity was ensured and compared in 2D and 3D cell culture.

Keywords

Curcumin
Turmeric
curcuminoids
drug delivery
drug formulation
NMR
XRD
solid amorphous dispersion
drug solubilization
MDA-MB-231
3D cell culture
poly(2-oxazoline)
poly(2-oxazine)
ultra-high loading
Chemistry
Health Sciences

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