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Cu_oxygen_tyrosinase.pdf (2.93 MB)
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Copper–oxygen Dynamics in Tyrosinase

preprint
submitted on 06.08.2019 and posted on 06.08.2019 by Nobutaka Fujieda, Sachiko Yanagisawa, Minoru Kubo, Genji Kurisu, Shinobu Itoh
To unveil the activation of dioxygen on the copper centre (Cu2O2core) of tyrosinase, we performed X-ray crystallograpy with active-form tyrosinase at near atomic resolution. This study provided a novel insight into the catalytic mechanism of the tyrosinase, including the rearrangement of copper-oxygen species as well as the intramolecular migration of copper ion induced by substrate-binding.

Funding

JSPS KAKENHI Grant Number JP15K13743

JSPS KAKENHI Grant Number JP15H01066

JSPS KAKENHI Grant Number JP17H05233

JSPS KAKENHI Grant Number JP16H01025

JSPS KAKENHI Grant Number JP18H04270

JST CREST (# JPMJCR16P1)

Kao Melanin Workshop

History

Email Address of Submitting Author

fujieda@biochem.osakafu-u.ac.jp

Institution

Osaka Prefecture University

Country

Japan

ORCID For Submitting Author

0000-0003-1045-6063

Declaration of Conflict of Interest

No conflict of interest.

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