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Carbonyl Sulfide-Mediated Synthesis of Peptides with Amino Acid Ionic Liquids

preprint
submitted on 12.12.2019 and posted on 18.12.2019 by Ming Chen, Xihan Yu
Carbonyl sulfide (OCS), the component of volcanic emission, has been found to induce the condensation of amino acids under simulated primordial earth conditions. However, the applications of OCS in peptide chemical synthesis is still limited by their heterogeneities and low efficiencies. We herein report an OCS-mediated approach for solid-phase peptide synthesis using amino acid ionic liquids as recyclable reactants. The coupling reactions required no base and solvent and was completed in minutes at room temperature. The applicability and sustainability of this approach were demonstrated by the facile syntheses of peptides with remarkably high yields.

History

Email Address of Submitting Author

mingchen@mail.ecust.edu.cn

Institution

Yan’an University

Country

China

ORCID For Submitting Author

0000-0001-7074-9840

Declaration of Conflict of Interest

no conflict of interest

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