Carbon-Heteroatom Cross-Coupling via an Electronically Excited Nickel (II) Complex

2019-08-28T17:48:23Z (GMT) by Randolph Escobar Jeffrey Johannes
While carbon-heteroatom cross coupling reactions have been extensively studied, many methods are specific and
limited to a set of substrates or functional groups. Reported here is a method that allows for C-O, C-N and C-S cross coupling reactions under one general methodology. We propose that an energy transfer pathway, in which an iridium photosensitizer produces an excited nickel (II) complex, is responsible for the key reductive elimination step that couples aryl halides to 1° and 2° alcohols, anilines, thiophenols, carbamates and sulfonamides.