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Carbon-Heteroatom Cross-Coupling via an Electronically Excited Nickel (II) Complex

preprint
submitted on 27.08.2019 and posted on 28.08.2019 by Randolph Escobar, Jeffrey Johannes
While carbon-heteroatom cross coupling reactions have been extensively studied, many methods are specific and
limited to a set of substrates or functional groups. Reported here is a method that allows for C-O, C-N and C-S cross coupling reactions under one general methodology. We propose that an energy transfer pathway, in which an iridium photosensitizer produces an excited nickel (II) complex, is responsible for the key reductive elimination step that couples aryl halides to 1° and 2° alcohols, anilines, thiophenols, carbamates and sulfonamides.

History

Email Address of Submitting Author

jeffrey.johannes@astrazeneca.com

Institution

AstraZeneca

Country

United States

ORCID For Submitting Author

0000-0001-7242-6682

Declaration of Conflict of Interest

The authors declare no competing financial interest.

Version Notes

version 1.0

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