Asymmetric Chemoenzymatic Synthesis of Podophyllotoxin and Related Aryltetralin Lignans

2019-04-04T16:12:17Z (GMT) by Jian Li Xiao Zhang Hans Renata
We report a concise chemoenzymatic synthesis of podophyllotoxin. Highlights of the synthesis include the use of enzymatic oxidative coupling to generate the tetracyclic core of the natural product, and late stage chemical oxidation to install the requisite secondary alcohol.