Expanding the Family of Tetrahalide Iron Complexes: Synthesis, Structure and Biological Applications.

14 August 2020, Version 2

Abstract

A neutral octahedral mononuclear iron(II) tetrabromide complex, [Fe(Hampy)2Br4], that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised through redox chemistry and analysed using X-ray crystallography. The iron(II) oxidation state is balanced by the protonated pyrazinium nitrogen just outside the coordination sphere. The biological properties of this and two other related complexes are investigated using both Gram-negative and Gram-positive bacteria as well as methicillin resistant strains. They all exhibit some antimicrobial properties albeit at moderate to poor concentrations. However, the tetrahalide complexes analysed exhibit excellent anti biofilm properties well below cytotoxic levels.

Keywords

antimicrobial chemicals
Iron Complexes
MRSA biofilms
transition metal toxicity
Coordination Complexes
bioinorganic interactions

Supplementary materials

Title
Description
Actions
Title
Expanding the Family of Tetrahalide Iron Complexes SI
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.