An Alternate Energy-Conserved Pathway for the Morita-Baylis-Hillman (MBH) Reaction

Veejendra Yadav

doi:10.26434/chemrxiv.12011673.v2

Organic Chemistry

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An Alternate Energy-Conserved Pathway for the Morita-Baylis-Hillman (MBH) Reaction

20 July 2020, Version 2

Working Paper

Veejendra Yadav

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An new overall lower energy pathway for the amine-catalysed Morita-Baylis-Hillman reaction is proposed from computations at the M06-2X/6-311++G(d,p) level. The pathway involves proton-transfer from the ammonium ion to the alkoxide formed from the aldol reaction through a seven-membered ring transition state (TS) structure followed by highly exothermic Hofmann elimination through a five-membered ring TS structure to form the product and also release the catalyst to carry on with the process all over again.

Keywords

Morita-Baylis-Hillman Reaction

proton-transfer

Hofmann elimination

Supplementary materials

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