A Sweet Galactose Transfer – Metabolic Oligosaccharide Engineering as a Tool to Study Glycans in Plasmodium Infection

07 November 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The use of artificial galactose derivatives and labelling through iEDDA reaction in the liver stage of Plasmodium infection showed increased uptake in infected hepatic cells, through participation of GLUT1 transporters. Furthermore, unprotected derivatives are transferred from the mosquito host to the Plasmodium berghei parasite. This strategy has the potential to provide new insights into Plasmodium glycobiology.

Keywords

bioorthogonal chemistry
inverse electron-demand Diels–Alder
carbohydrates
GLUT1 transporters
malaria
liver stage malaria

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