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    22588 results for search term: COVID-19

    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    Gliptin Repurposing for COVID-19

    , Authors: Matthew Groves, Alexander Domling, Angel Jonathan Ruiz Moreno, Atilio Reyes Romero, Constantinos Neochoritis, Marco Velasco-Velázquez
    Version 1 posted 15 April 2020

    Extract found to contain search terms

    Drug repurposing aims to discover novel indications for already approved 34 drugs.3 The overwhelming advantage of drug repurposing is the much faster clinical approval, due to 35 already extensive knowledge of the physicochemical properties and behavior of the drug in humans. 36 Therefore, many groups have pursued a drug repurposing approach. This has led to several promising 37 drugs which are currently tested for COVID-19 in humans, including Favipiravir, Remdesivir, HIV protease 38 inhibitors, chloroquine or Tozilizumab.4,5 So far, however, none showed more than promising activity 39 based on low numbers of patients per trial. Additionally, a combination of Lopinavir and Ritonavir 40 (Kaletra®) – effective for HIV infection – failed in ~200 severe COVID-19
    1,054
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    3
    Citations
    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    COVID-KOP: Integrating Emerging COVID-19 Data with the ROBOKOP Database

    , Authors: Daniel Korn, Tesia Bobrowski, Michael Li, Yaphet Kebede, Patrick Wang, Phillips Owen, Gaurav Vaidya, Eugene Muratov, Rada Chirkova, Cristopher Bizon, Alexander Tropsha
    Version 1 posted 18 June 2020

    Extract found to contain search terms

    In response to the COVID -19 pandemic, we established COVID -KOP, a new knowledgebase integrating the existing ROBOKOP biomedical knowledge graph with information from recent biomedical literature on COVID -19 annotated in the CORD-19 collection. COVID -KOP can be used effectively to test new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID -19 . COVID
    772
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    Category: Biological and Medicinal Chemistry
    ,
    Review
    , Title:

    Fluorine in Medicinal Chemistry: In Perspective to COVID-19

    , Authors: CHENG ZHANG
    Version 1 posted 02 March 2022

    Extract found to contain search terms

    Over two years into the outbreak of COVID -19 , the quest for effective and economical drugs has become starkly clear to reduce the risk of progression of coronavirus disease. A number of drugs have been investigated and they can be taken orally at home and be used after exposure to SARS-CoV-2 or at the first sign of COVID -19 . Fluorinated oral anti-COVID -19 drugs—including Paxlovid, the first oral tablet for the treatment of COVID -19 —is an important subgroup. Fluorine has been widely used in pharmaceuticals market and can lead to improved selectivity indices, increased lipophilicity, greater metabolic stability, and in this case the improved anti-COVID -19
    791
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    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    A Translatable Subunit Nanovaccine for COVID-19

    , Authors: Lixin Liu, Zhijia Liu, Haolin Chen, Hong Liu, Qiang Gao, Feng Cong, Guangxia Gao, Yongming Chen
    Version 1 posted 15 May 2020

    Extract found to contain search terms

    Most importantly, the nanovaccine can elicit strong IgA antibody, providing potential mucosal protection to host. Altogether, this study offers a translatable design for a potent subunit SARS-CoV-2 nanovaccine. Keywords: COVID-19 ; Cellular immunity; Humoral immunity; Liposome; SARS- CoV-2; Subunit vaccine. 2 1. Introduction The new emergence severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) causes pandemic in the worldwide. Until May 12, 2020, the number of coronavirus induced disease (COVID-19 ) cases is over 4 million cases and COVID- 19
    1,316
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    2
    Citations
    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    Repurposing of SARS Inhibitors Against COVID 19

    , Authors: Priyanka Rajbhar, Dikshant Singh, Ruchi Yadav
    Version 1 posted 24 April 2020

    Extract found to contain search terms

    Homology modelling and docking studies has been mainly done to identify the interaction and binding affinity of previous drugs and how they could act as a potential solution to stop the overall spread of the disease in case of pandemic like COVID -19
    703
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    1
    Citations
    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    Dose COVID-19 Uncovered a New Feature of Metronidazole Drug?Dose COVID-19 Uncover a New Feature of Metronidazole Drug?

    , Authors: Mohammad Seyedhamzeh, Bahareh Farasati Far, Mehdi Shafiee Ardestani, Shahrzad Javanshir, Fatemeh Aliabadi, Hamed Reyhanfard, Hamidreza Pazoki-Toroudi
    Version 3 posted 08 October 2020

    Extract found to contain search terms

    Studies of coronavirus disease 2019 (COVID -19
    1,213
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    Category: Theoretical and Computational Chemistry
    ,
    Working Paper
    , Title:

    COVID-19 Knowledge Extractor (COKE): A Tool and a Web Portal to Extract Drug - Target Protein Associations from the CORD-19 Corpus of Scientific Publications on COVID-19

    , Authors: Daniel Korn, Vera Pervitsky, Tesia Bobrowski, Vinicius Alves, Charles Schmitt, Cristopher Bizon, Nancy Baker, Rada Chirkova, Artem Cherkasov, Eugene Muratov, Alexander Tropsha
    Version 1 posted 26 November 2020

    Extract found to contain search terms

    Objective: The COVID -19 pandemic has catalyzed a widespread effort to identify drug candidates and biological targets of relevance to SARS-COV-2 infection, which resulted in large numbers of publications on this subject. We have built the COVID -19 Knowledge Extractor (COKE), a web application to extract, curate, and annotate essential drug-target relationships from the research literature on COVID -19
    661
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    1
    Citations
    Category: Biological and Medicinal Chemistry
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    Working Paper
    , Title:

    Text and Network-Mining for COVID-19 Intervention Studies

    , Authors: Aditya Rao, VG Saipradeep, Thomas Joseph, Sujatha Kotte, Naveen Sivadasan, Rajgopal Srinivasan
    Version 2 posted 06 May 2020

    Extract found to contain search terms

    Amongst the novel repurposing drugs predicted, laninamivir and paritaprevir are possible COVID -19 anti-viral drugs while pranlukast was postulated to be a candidate for managing severe respiratory symptoms in COVID -19
    1,025
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